Another important property of Bacopa is its support for neurological health, including its role in maintaining normal nervous system function.
One study investigated the role of Bacopa monnieri in supporting neurological health and its potential to maintain normal nervous system function in animal models. Aqueous and alcoholic extracts of Bacopa were given to rats, showing a notable influence in promoting well-being under conditions designed to model stress on the nervous system. The research highlighted that with certain dosages, Bacopa extracts contributed to a balanced activity without inducing sedation or affecting coordination, emphasizing its value in holistic wellness approaches to support neurological function.
Another study explored the supportive effects of Brahmi Rasayan on maintaining neurological health in mice. The formula, administered in doses ranging from 1 to 30 gm/kg, was observed to support well-being in conditions modeled to stress the nervous system, alongside promoting comfort by moderating the perception of discomfort. The research noted that, at certain doses, Brahmi Rasayan was associated with a calming effect on the animals. Further investigations into the formula’s impact, particularly in rat models, highlighted its potential in supporting normal neurological responses, emphasizing its contribution to holistic approaches aimed at enhancing neurological function and overall wellness.
Protection from phenytoin-induced cognitive deficit
The side effects of phenytoin, the commonly used anti-epileptic drug, include impairment of cognitive functions. Bacopa monnieri extract was evaluated for efficacy in reversing this side effect in animal models. Evaluations with regard to passive avoidance response task (PA), maximal electroshock seizures and locomotor activity were performed in mice. The mice received phenytoin (25 mg/kg orally for 14 days). Bacopa monnieri (40 mg/kg for 7 days) given along with phenytoin in the second week of the two-week regimen significantly reversed PHT-induced impairment of cognitive function as determined from the PA results. Both acquisition and retention of memory were improved without affecting the anti-convulsant activity of PHT. These effects were independent of motor stimulation. The authors concluded that Bacopa monnieri has potential use in correcting the cognitive deficit induced by PHT.
Postulated mode of action
It’s suggested that the supportive effects on neurological health might be linked to the action of GABA (gamma-aminobutyric acid), which plays a key role in neural impulse transmission. Compounds that enhance GABA activity are recognized for their potential to support calmness, comfort, and overall neurological function.
Further research highlighted the potential of an alcoholic extract of Bacopa monnieri in influencing smooth muscle activity in animal studies. This extract was shown to moderate the spontaneous movements in smooth muscles, suggesting a direct impact on muscle relaxation. The observed effects were particularly noted in the context of calcium ion flow, with the extract demonstrating an ability to interfere with calcium influx into cells, thereby supporting muscle relaxation without significantly affecting other calcium mobilization pathways.
Comprehensive analyses of Bacopa monnieri and its components, such as Bacoside A and Bacoside B, underline the herb’s role in supporting cognitive health at nuanced levels. The saponins present in the extract, especially when applied in focused studies, have been linked to enhanced cognitive function, showcasing the broad spectrum of Bacopa monnieri’s potential benefits in supporting neurological and muscular health